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Visualization of the Covid-19 virus

Investigating S-acylation of the SARS-Cov-2 Spike Protein Leads to New Insights into Viral Infectivity

A better understanding of coronavirus biology can enable development of new antivirals to help stop COVID-19 and prevent future pandemics. In recent work, Puthenveetil et al. characterized S-acylation of the Spike (S) protein of SARS-CoV-2. This post-translational modification is known to be important to the viral replication cycle of other viruses across multiple virus families […]

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Black tube sponges

The mechanism of action of a potential anti-cancer therapeutic: new technique to monitor subcellular environments

Callyspongiolide (CSG), derived from marine sponges, is highly toxic to human cancer cell lines from a variety of origin tissues and presents a potential cell-killing agent to be included in antibody-drug conjugates for anti-cancer therapeutics. CSG-mediated cell death doesn’t appear to occur via the canonical apoptosis pathway because cell death is not blocked by caspase […]

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Two holding hands

Investigating the Mechanism of Pathology in Parkinson’s Disease

Parkinson’s disease (PD) is an age-related neurodegenerative disorder that affects almost 1 million people in the United States. PD is associated with motor symptoms including tremors and stiffness that affect balance and coordination. Symptoms appear as dopaminergic neurons are lost from the midbrain. Neuronal death appears to be due to the accumulation of toxic aggregates, […]

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