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Archive | COVID-19

Scientifically accurate atomic model of coronavirus

Intranasal administration of neutralizing IgA increases SARS-CoV-2 infection in a hamster model

Infectivity of SARS-CoV-2 is associated with high viral loads in the upper respiratory tract. Alpha and gamma immunoglobulins (IgA and IgG) both neutralize viral infections, with IgA significant in mucosal immunity and IgG predominantly affecting blood. Most studies focus on IgG in SARS-CoV-2 infection, but the role of IgA is less understood. To enter host […]

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Fig 4

N-terminomics of SARS-CoV-2

A better understanding of the interactions between SARS-CoV-2 and the host cells it infects could lead to new approaches to treat or prevent infections. Proteolysis is essential to the SARS-CoV-2 life cycle; two viral polyproteins must be cleaved to generate components of the viral replication/transcription complex. The polyproteins are snipped apart by two viral proteases, […]

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Visualization of the Covid-19 virus

Investigating S-acylation of the SARS-Cov-2 Spike Protein Leads to New Insights into Viral Infectivity

A better understanding of coronavirus biology can enable development of new antivirals to help stop COVID-19 and prevent future pandemics. In recent work, Puthenveetil et al. characterized S-acylation of the Spike (S) protein of SARS-CoV-2. This post-translational modification is known to be important to the viral replication cycle of other viruses across multiple virus families […]

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Coronavirus

Studying the SARS-CoV-2 proteases

Researchers at the Wroclaw University of Science and Technology and their colleagues have recently published exciting work improving our understanding of the two proteases encoded by the SARS-CoV-2 genome, the main protease (Mpro) and the papain-like protease (PLpro). These proteases are required for viral gene expression and for viral replication, so they are attractive targets […]

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