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Author Archive | Tram Tran

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Deciphering Lipid Metabolism in Borrelia burgdorferi (Bb) to Better Understand Lyme Disease

Lyme disease is the most common tick-born disease in the United States, with almost half a million cases diagnosed every year. Lyme disease is caused by the bacterium Borrelia burgdorferi (Bb), which is transmitted to humans when they are bitten by an infected tick. Bb does not produce any toxins, and the pathogenesis of Lyme […]

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Investigating the Mechanism of Pathology in Parkinson’s Disease

Parkinson’s disease (PD) is an age-related neurodegenerative disorder that affects almost 1 million people in the United States. PD is associated with motor symptoms including tremors and stiffness that affect balance and coordination. Symptoms appear as dopaminergic neurons are lost from the midbrain. Neuronal death appears to be due to the accumulation of toxic aggregates, […]

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How the Sapphire Scanner is Used to Better Grocery Store Tomatoes

Few things are more disappointing than a tasteless, mealy grocery store tomato. These bland fruits are pale imitations of the vine-ripened tomatoes available from the garden at the end of summer. Tomatoes are perishable, and providing ripe, high-quality tomatoes that maintain their texture and nutritional content is a challenge for commercial growers. A recent publication […]

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DNA

Sapphire Biomolecular Imager Used in Landmark Study of DNA Repair Pathway

The non-homologous end-joining (NHEJ) pathway is one of two pathways responsible for repairing double-stranded breaks in cellular DNA. Double-stranded breaks can be formed by ionizing radiation or mutagenic chemicals, or as intermediates during normal processes such as the recombination of DNA segments required to create antibody and T cell receptor diversity. In contrast to homologous […]

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